I. Enhanced Carriers for Transdermal Drug Delivery Systems
Thanks to its unique amphiphilic structure, silicone oil emulsions have become a key excipient in transdermal drug delivery systems. Through molecular design, the copolymerization of polydimethylsiloxane (PDMS) and polyoxyethylene ether segments allows for controlled particle sizes within the 50-200 nm range, significantly enhancing transdermal drug penetration. In nitroglycerin patches, this emulsion system increased the drug transdermal rate to 3.2 μg/cm²·h, a 40% increase compared to traditional liposome carriers, and maintained stable release for 24 hours. Clinical studies have shown that patches using silicone oil emulsions reduced angina pectoris attacks by 62% and achieved 91% patient compliance.

II. Experts in Skin Feel Optimization for Topical Preparations
To meet the specific needs of dermatological medications, silicone oil emulsions achieve customized skin feel through controlled emulsification processes. Silicone oil emulsions prepared using a three-phase emulsification technique (W/O/W) form a breathable, hydrated film on the skin surface, maintaining a moist wound environment while avoiding the sticky feel of traditional ointments. In the treatment of psoriasis, calcipotriol ointment containing 2% silicone oil emulsion reduced itch scores by 58% and increased skin hydration in the treated area to 45% (compared to 40%-60% for healthy skin). Furthermore, its non-ionic surface properties minimize interactions with active pharmaceutical ingredients, ensuring over 98% stability for photosensitive drugs like tretinoin.

III. Functional Coating Materials for Oral Preparations
Silicone oil emulsions exhibit excellent moisture and crack resistance in oral solid dosage forms. Film coatings prepared using methylvinyl silicone oil emulsions have a water vapor transmission rate (WVTR) as low as 0.2 g/(m²·24h), a 75% reduction compared to coatings based on hydropropyl methylcellulose. In probiotic tablet applications, this coating increases the viable bacterial survival rate from 65% to 92% and maintains integrity for two hours in gastric acid (pH 1.2), ensuring precise drug release in the intestine. Animal experiments have shown that ibuprofen sustained-release tablets coated with silicone oil emulsion reduced the blood concentration fluctuation coefficient (F) from 1.8 to 0.9, significantly reducing the risk of gastrointestinal irritation.

IV. Innovative Substrates for Biomedical Materials
Silicone oil emulsions are expanding their application in the biomedical field through functional modification. Silicone oil emulsion coatings grafted with heparin molecules can improve the anticoagulant properties of vascular stent surfaces by 10-fold and reduce platelet adhesion to 5% (compared to 85% for uncoated stents). In artificial joint lubricants, silicone oil emulsion composites containing perfluoropolyether exhibit an ultra-low friction coefficient (μ=0.003), approaching that of natural joint fluid. They are also stable in saline at 37°C for over 180 days, providing a long-lasting lubrication solution for high-end implantable devices.